Multi-scale Modelling and applications on HIV/AIDS transmission dynamics

发布时间：2025-11-17 作者：浏览次数：

Speaker:	肖燕妮	DateTime:	2025年11月21日(周五)下午15:30-18:30
Brief Introduction to Speaker: 肖燕妮，西安交通大学数学与统计学院副院长、数学与生命科学交叉研究中心主任、博士生导师，主要从事数据和问题驱动的传染病动力学的研究。参与完成了国家“十一五”、“十二五”和“十三五”科技重大专项艾滋病领域的建模研究。主持国家自然科学基金多项，包括重点项目1项、重点国际合作1项，主持科技部重点研发课题1项。2022年至今任中国生物数学专业委员会主任，2020年起任国务院第八届学科评议组成员（数学）。		Place:	国交2号楼315会议室
Abstract:Modelling on various scales becomes challenging in accurately describing the process of disease spreading. In this talk I shall briefly give an introduction to modelling approach at population/individual level. I shall give an idea of developing a multi-scale model that nests the within-host viral dynamics into the between-host transmission model, and then I present our recent work on the bidirectional coupling of between-host dynamics and within-host dynamics by including perceived risk and behavioral dynamics. The model can exhibit rich dynamic behaviors including the periodic oscillations of the solutions, the discordance of transmission dynamics and viral dynamics. It is also observed that new infections may increase with improving treatment efficacy. Further, I present main results on multi-objective optimal control problems, based on the single objective optimal control problem on between-host or within-host level. Finally I shall give concluding remarks on multi-scale modelli...

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